|Western Blot (WB)||0.25-1 µg/ml|
|Tested Species reactivity||Human, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (362 KSIHLPEKSVPSERGLSP 379) of IkZF3, Zinc finger protein Aiolos protein.|
|Purification||Antigen affinity chromatography|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
IKZF3 is a hemopoietic zinc finger DNA-binding protein that acts as a central regulator of lymphoid differentiation and is implicated in leukemogenesis. It is a 509 amino acid containing nuclear protein and a member of the IKAROS family of C2H2- type zinc-finger proteins and zinc finger protein, subfamily 1A with six C2H2- type zinc-fingers. IKZF3 may form homodimers or heterodimers and is known to interact with IKZF4 and IKZF5. A well known transcription factor, IKZF3, plays an important role in the regulation of B lymphocyte proliferation and differentiation and participates in chromatin remodeling. IKZF3 plays a role in the control of T cell death by regulating the expression of BCL2 in acute lymphoblastic leukemia. Strong expression of IKZF3 is usually detected in peripheral blood leukocytes, spleen and thymus and low expression in liver, small intestine, and lung.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 3 (Aiolos); AIO; AIOLOS; IKAROS family zinc finger 3 (Aiolos); Ikaros family zinc finger protein 3; subfamily 1A; zinc finger DNA binding protein Aiolos; zinc finger protein; Zinc finger protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos); ZNFN1A3
Gene Aliases: AIO; AIOLOS; IKZF3; ZNFN1A3
UniProt ID: (Human) Q9UKT9
Entrez Gene ID: (Human) 22806
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.