|Flow Cytometry (Flow)||Assay Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||purified platelet membrane glycoproteins|
|Contains||0.08% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Integrin beta3, also known as CD61, is a 130 kDa transmembrane glycoprotein that binds noncovalently in complexes with integrin alpha subunits to form the functional receptor that binds to specific extracellular matrix proteins (e.g., fibronectin, vitronectin, etc.). Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrin receptors on the cell surface and their binding to the extracellular matrix leads to the formation of focal contacts and the activation of various signal transduction pathways. Phosphorylation of tyrosine 773 on Integrin beta3 activates the receptor and promotes cell adhesion. Tyr773 is commonly referred to as Tyr747, the corresponding site in the chicken Integrin beta3 protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: antigen CD61; BDPLT2; CD61; GP3A; GPIIIa; integrin beta 3; Integrin beta-3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITGB3; platelet glycoprotein IIIa; Platelet membrane glycoprotein IIIa
Gene Aliases: BDPLT16; BDPLT2; CD61; GP3A; GPIIIa; GT; ITGB3
UniProt ID: (Human) P05106
Entrez Gene ID: (Human) 3690
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