|ELISA (ELISA)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Western Blot (WB)||See 1 publications below|
|Tested Species reactivity||Human, Mouse|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Synthetic peptide derived from the internal region of JAB1|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the "Signalosome", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 38 kDa Mov34 homolog; COP9 complex S5; COP9 constitutive photomorphogenic homolog subunit 5; COP9 signalosome complex subunit 5; CSN5; JAB1; Jun activation domain-binding protein 1; Jun coactivator; Kip1 C-terminus-interacting protein 2; MOV-34; SGN5; signalosome subunit 5; testis secretory sperm-binding protein Li 231m
Gene Aliases: AI303502; COPS5; CSN5; JAB1; Kic2; MOV-34; Mov34; SGN5
Molecular Function: transcription factor
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