|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 198 of Human JAB1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29872 targets JAB1 in IF and WB applications and shows reactivity with Human and mouse samples.
The PA5-29872 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 198 of Human JAB1.
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 38 kDa Mov34 homolog; COP9 complex S5; COP9 constitutive photomorphogenic homolog subunit 5; COP9 signalosome complex subunit 5; CSN5; JAB1; Jun activation domain-binding protein 1; Jun coactivator; Kip1 C-terminus-interacting protein 2; MOV-34; SGN5; signalosome subunit 5; testis secretory sperm-binding protein Li 231m
Gene Aliases: AI303502; COPS5; CSN5; JAB1; Kic2; MOV-34; Mov34; SGN5
Molecular Function: transcription factor
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