|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 118 and 390 of Human JNK3|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29707 targets JNK3 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29707 immunogen is recombinant fragment corresponding to a region within amino acids 118 and 390 of Human JNK3.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: c-Jun N-terminal kinase 3; JNK3; JNK3 alpha protein kinase; JNK3A; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; Mitogen-activated protein kinase 10; p493F12; p54bSAPK; PRKM10; SAPK1b; stress activated protein kinase beta; Stress-activated protein kinase 1b; Stress-activated protein kinase JNK3
Gene Aliases: JNK3; JNK3A; MAPK10; p493F12; p54bSAPK; PRKM10; SAPK1B
UniProt ID: (Human) P53779
Entrez Gene ID: (Human) 5602
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