|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the C-terminal region of human KCNAB3|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 50% glycerol, 150mM NaCl|
|Contains||0.02% sodium azide|
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha subunits (KV), which include the KV1, KV2, KV3 and KV4 proteins, and accessory or KV-subunits that modify the gating properties of the coexpressed KV subunits. KV beta.3 is an accessory K+ channel protein which regulates the activity of the pore-forming alpha subunit and alters the functional properties of Kv1.5. KV beta.3 localizes to the cytoplasm and is expressed in the brain, with highest expression detected in the cerebellum, and weakest expression seen in the frontal and temporal lobes. No KV beta.3 expression is detected in the heart, spinal cord, lung, liver, kidney, pancreas, placenta or skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: K(+) channel subunit beta-3; KCNA3B; KCNAB3; Kv-beta-3; KV-beta.3; potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 3; potassium channel, voltage gated subfamily A regulatory beta subunit 3; potassium channel, voltage-dependent, beta-3 subunit; potassium voltage gated channel, shaker related subfamily, beta member 3; potassium voltage-gated channel, shaker-related subfamily, beta member 3; RCK beta3; Voltage-gated potassium channel subunit beta-3
Gene Aliases: AKR6A9; C330022D06Rik; Ckbeta3; KCNA3.1B; KCNA3B; KCNAB3; Kcnab4; KV-BETA-3; mKv(beta)4
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.