|Flow Cytometry (Flow)||1:200 - 1:400|
|Western Blot (WB)||1:500 - 1:2000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human KEAP1 (amino acids: 380-624) expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
MA5-17106 targets KEAP1 in FACS, ICC, IF and WB applications and shows reactivity with Human and Mouse samples.
The MA5-17106 immunogen is purified recombinant fragment of human KEAP1 (amino acids: 380-624) expressed in E. Coli.
MA5-17106 detects KEAP1 which has a predicted molecular weight of approximately 69.7kDa.
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cytosolic inhibitor of Nrf2; INrf2; Kelch-like ECH-associated protein 1; kelch-like family member 19; Kelch-like protein 19; NRF2 cytosolic inhibitor; ring canal protein
Gene Aliases: INRF2; KEAP1; KIAA0132; KLHL19; mKIAA0132
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