|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 938 and 1152 of Human KIAA0196|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30337 targets KIAA0196 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30337 immunogen is recombinant fragment corresponding to a region within amino acids 938 and 1152 of Human KIAA0196.
This gene encodes a 134 kDa protein named strumpellin that is predicted to have multiple transmembrane domains and a spectrin-repeat-containing domain. This ubiquitously expressed gene has its highest expression in skeletal muscle. The protein is named for Strumpell disease; a form of hereditary spastic paraplegia (HSP). Spastic paraplegias are a diverse group of disorders in which the autosomal dominant forms are characterized by progressive, lower extremity spasticity caused by axonal degeneration in the terminal portions of the longest descending and ascending corticospinal tracts. More than 30 loci (SPG1-33) have been implicated in hereditary spastic paraplegia diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: SPG8; Strumpellin; WASH complex subunit 5; WASH complex subunit strumpellin
Gene Aliases: KIAA0196; RTSC; RTSC1; SPG8; WASHC5
UniProt ID: (Human) Q12768
Entrez Gene ID: (Human) 9897
Molecular Function: transfer/carrier protein
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