|Immunohistochemistry (Paraffin) (IHC (P))||1:200|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||A synthetic peptide derived from human Kif 7|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 150mM NaCl, 50% glycerol|
|Contains||0.02% sodium azide|
Do not aliquot.
This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies. [provided by RefSeq, Oct 2011].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EQYK340; kinesin 7; Kinesin-like protein KIF7
Gene Aliases: ACLS; AGBK; HLS2; JBTS12; KIF7; UNQ340; UNQ340/PRO539
UniProt ID: (Human) Q2M1P5
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