|Western Blot (WB)||1/500 - 1/2000|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human KLHL12 expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
MA5-15649 targets KLHL12 in WB applications and shows reactivity with Human samples.
The MA5-15649 immunogen is purified recombinant fragment of human KLHL12 expressed in E. Coli.
MA5-15649 detects KLHL12 which has a predicted molecular weight of approximately 63kDa.
Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.Tissue specificity: Highly expressed in testis and at lower levels in the submandibular salivary gland.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C3IP1; CUL3-interacting protein 1; DKIR; DKIR homolog; FLJ27152; hDKIR; kelch-like family member 12; Kelch-like protein 12; kelch-like protein C3IP1; KLHL12
Gene Aliases: C3IP1; DKIR; KLHL12
UniProt ID: (Human) Q53G59
Entrez Gene ID: (Human) 59349
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