|Immunocytochemistry (ICC)||10 ug/ml|
|Immunofluorescence (IF)||20 ug/ml|
|Western Blot (WB)||1-2 ug/ml|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 14 amino acid peptide near the carboxy end of human KPNA3.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is EL4 cell lysate.
PA5-21035 can be used with blocking peptide PEP-1149.
Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA3, the alpha subunit 3 of karyopherin, is silimar to human KPNA2, suggesting that KPNA3 may be involved in the nuclear transport system. It is ubiquitously expressed and recent studies have shown that human KPNA3 may be associated with schizophrenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: importin alpha 4; Importin alpha Q2; importin alpha-3; importin subunit alpha-3; Importin subunit alpha-4; importin-alpha-Q2; karyopherin (importin) alpha 3; karyopherin alpha 3 (importin alpha 4); Karyopherin subunit alpha-3; predicted role in nuclear import; Qip2; RP11-432M24.3, IPOA4, SRP1, SRP1gamma, SRP4, hSRP1; SRP1-gamma
Gene Aliases: hSRP1; importin; IPOA4; KPNA3; QIP2; SRP1; SRP1gamma; SRP4
Molecular Function: transfer/carrier protein
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