|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 20 and 307 of Human KPNA5|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29460 targets KPNA5 in IF and WB applications and shows reactivity with Human samples.
The PA5-29460 immunogen is recombinant fragment corresponding to a region within amino acids 20 and 307 of Human KPNA5.
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: importin alpha 6; Importin subunit alpha-6; IPOA6; karyopherin alpha 5 (importin alpha 6); Karyopherin subunit alpha-5; SRP6
Gene Aliases: IPOA6; KPNA5; SRP6
UniProt ID: (Human) O15131
Entrez Gene ID: (Human) 3841
Molecular Function: transfer/carrier protein
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