|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 6-37 amino acids from the N-terminal region of human Kremen|
|Purification||Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Kremen is a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Dickkopf receptor; Kremen protein 1; Kringle domain-containing transmembrane protein 1; kringle-coding gene marking the eye and the nose; Kringle-containing protein marking the eye and the nose
Gene Aliases: KREMEN; KREMEN1; KRM1
UniProt ID: (Human) Q96MU8
Entrez Gene ID: (Human) 83999
Molecular Function: receptor
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