|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 1 and 183 of Human LDB3|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30434 targets LDB3 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30434 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 183 of Human LDB3.
This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1 and 2) have C-terminal LIM domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cardiomyopathy, dilated 1C (autosomal dominant); CMD1C; CYPHER; LDB3; LDB3Z1; LDB3Z4; LIM domain-binding protein 3; LVNC3; ORACLE; oracle protein; PDLIM6; PDZ and LIM domain 6; PDZ-LIM domain protein; Protein cypher; Protein oracle; Z-band alternatively spliced PDZ motif protein; Z-band alternatively spliced PDZ-motif protein; ZASP
Gene Aliases: AW742271; CMD1C; CMH24; CMPD3; CYPHER; KIAA0613; LDB3; LDB3Z1; LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP
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