|Immunofluorescence (IF)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Mouse|
|Host / Isotype||Sheep / IgG|
|Immunogen||Protein corresponding to residues 2-447 of the Lfc protein fused to GST.|
|Purification||Ammonium sulfate precipitation|
|Contains||0.08% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Lfc is a 118 kDa protein discovered in a screen for oncogenes in NIH 3T3 cells. Lfc is a signaling protein related to Lbc and is part of the Dbl family of proteins. Lfc is a guanine-nucleotide exchange factor (GEF) for the Rho family of small GTPases. Lfc has also been shown to be upstream of the serine-threonine kinase JNK. Lfc has also been shown to mediate the activation of the Rac signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AA408978; GEF-H1; GEFH1; Guanine nucleotide exchange factor H1; LBC'S first cousin; Lbcl1; Lfc; LFP40; Lymphoid blast crisis-like 1; mKIAA0651; Oncogene LFC; Rho guanine nucleotide exchange factor 2; Rhobin
Gene Aliases: AA408978; Arhgef2; GEF; GEF-H1; GEFH1; Kiaa0651; Lbcl1; Lfc; LFP40; mKIAA0651; P40
UniProt ID: (Mouse) Q60875
Entrez Gene ID: (Mouse) 16800
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