|Western Blot (WB)||1:1000-1:10,000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 178 and 425 of Human LGI1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28291 targets LGI1 in WB applications and shows reactivity with Human samples.
The PA5-28291 immunogen is recombinant fragment corresponding to a region within amino acids 178 and 425 of Human LGI1.
This gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADLTE; ADPAEF; EPITEMPIN; Epitempin-1; EPT; ETL1; IB1099; leucine-rich glioma inactivated 1; Leucine-rich glioma-inactivated protein 1; leucine-rich, glioma inactivated 1
Gene Aliases: ADLTE; ADPAEF; ADPEAF; EPITEMPIN; EPT; ETL1; IB1099; LGI1; UNQ775/PRO1569
UniProt ID: (Human) O95970
Entrez Gene ID: (Human) 9211
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