|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||Assay-Dependent|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 227 of Human LIN7A|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30871 targets LIN7A in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-30871 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 227 of Human LIN7A.
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hLin-7; lin 7 homolog a; LIN-7A; LIN7; MALS-1; mammalian LIN-7 1; Mammalian lin-seven protein 1; mLin-7; Protein lin-7 homolog A; Tax interaction protein 33; TIP-33; Veli-1; VELI1; vertebrate homolog of C. elegans Lin-7 type 1; Vertebrate lin-7 homolog 1; vertebrate LIN7 homolog 1
Gene Aliases: AI848705; LIN-7A; LIN7; LIN7A; MALS-1; MALS1; TIP-33; Veli; VELI1
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.