|Flow Cytometry (Flow)||0.1 µg/10^6 cells|
|Tested Species reactivity||Mouse|
|Host / Isotype||Rat / IgG2a, kappa|
|Contains||0.1% sodium azide|
|Storage conditions||4° C|
Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the ligand of HML-1 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD49 antigen-like family member D; CD49d; Integrin alpha-4; Integrin alpha-4/beta-7; Integrin alpha-IV; integrin alpha4B; Integrin beta-7; Integrin beta-P; Itga4; ITGB7; LPAM subunit alpha; Lymphocyte Peyer patch adhesion molecules subunit alpha; M290 IEL antigen; Peyer patches-specific homing receptor LPAM-1; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha
Gene Aliases: CD49D; Itga4; Itga4B; Itgb7; Ly69
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