|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (ERVEKTTGDKRT) corresponding to the internal amino acids of LRP5|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with mouse and rat based on sequence homology.
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BMND1; EVR1; EVR4; exudative vitreoretinopathy 1; HBM; HGNC:6697; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; Low-density lipoprotein receptor-related protein 5; LR3; LRP-5; LRP5; LRP7; OPPG; OPS; OPTA1; osteoporosis pseudoglioma syndrome; VBCH2
Gene Aliases: BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP5; LRP7; OPPG; OPS; OPTA1; VBCH2
UniProt ID: (Human) O75197
Entrez Gene ID: (Human) 4041
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