|Western Blot (WB)||2 µg/ml|
|Immunohistochemistry (IHC)||See 1 publications below|
|Immunohistochemistry (Paraffin) (IHC (P))||See 1 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Mouse Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues C L(1356) P N I R K Q P D G Y D Y Y A F S K D Q(1374) of human Lubricin.|
|Storage buffer||PBS with 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA3-118 detects Lubricin in human samples.
PA3-118 has been successfully used in Western blot procedures. By Western blot, this antibody detects a 280 kDa protein representing recombinant human Lubricin. PA3-118 works best on purified or recombinant samples under non-reducing conditions.
PA3-118 immunogen is a synthetic peptide corresponding to residues C L(1356) P N I R K Q P D G Y D Y Y A F S K D Q(1374) of human Lubricin. This polyclonal antibody has been referred to as: JSCLPN.
Lubricin is a glycoprotein encoded by the PRG4 gene. It has been identified as a component of joint lubrication and synovial homeostasis by reducing friction in joints and preventing synovial cell overgrowth. It is a large, water soluble molecule that acts as a carrier for insoluble surface-active phospholipid (SAPL). Depletion of lubricin function has been associated with camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP), an arthritic-like autosomal recessive disorder.
Protein Aliases: articular superficial zone protein; hemangiopoietin; Lubricin; Megakaryocyte stimulating factor; Megakaryocyte-stimulating factor; Proteoglycan 4; Proteoglycan-4 (PRG4).; Superficial zone proteoglycan
Gene Aliases: CACP; HAPO; JCAP; MSF; PRG4; SZP
UniProt ID: (Human) Q92954
Entrez Gene ID: (Human) 10216