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Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: family with sequence similarity 213, member A; peroxiredoxin (PRX)-like 2 activated in M-CSF stimulated monocytes; Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes; Peroxiredoxin-like 2A; Protein PAMM; Redox-regulatory protein FAM213A; redox-regulatory protein PAMM; UPF0765 protein C10orf58
Gene Aliases: C10orf58; FAM213A; PAMM; PRO2290; PRXL2A; PSEC0139; UNQ611/PRO1198
UniProt ID: (Human) Q9BRX8
Entrez Gene ID: (Human) 84293
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