|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 81-108 amino acids from the N-terminal region of human MAGEA2|
|Purification||Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
MAGEA2 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80% sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cancer/testis antigen 1.2; CT1.2; MAGE-2 antigen; melanoma antigen 2; melanoma antigen family A, 2B; melanoma antigen family A2B; melanoma antigen, family A, 2, copy b; Melanoma-associated antigen 2
Gene Aliases: CT1.2; MAGE2; MAGEA2; MAGEA2A; MAGEA2B
UniProt ID: (Human) P43356
Entrez Gene ID: (Human) 266740
Molecular Function: cell adhesion molecule
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