|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 62 and 372 of Human MAGI3|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-31449 targets MAGI3 in WB applications and shows reactivity with Human samples.
The PA5-31449 immunogen is recombinant fragment corresponding to a region within amino acids 62 and 372 of Human MAGI3.
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: dJ730K3.2; MAGI-3; membrane-associated guanylate kinase; Membrane-associated guanylate kinase inverted 3; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; membrane-associated guanylate kinase-related 3; RP4-730K3.1; WW and PDZ domain-containing protein 3
Gene Aliases: dJ730K3.2; KIAA1634; MAGI-3; MAGI3
UniProt ID: (Human) Q5TCQ9
Entrez Gene ID: (Human) 260425
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