|Western Blot (WB)||1:1000-1:10,000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 47 and 246 of Human MARCH2|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30620 targets MARCH2 in WB applications and shows reactivity with Human samples.
The PA5-30620 immunogen is recombinant fragment corresponding to a region within amino acids 47 and 246 of Human MARCH2.
MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 18.104.22.168). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E3 ubiquitin-protein ligase MARCH2; MARCH-II; membrane associated ring finger 2; membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; RING finger protein 172; RING-type E3 ubiquitin transferase MARCH2; RNF172
Gene Aliases: HSPC240; MARCH-II; MARCH2; RNF172
UniProt ID: (Human) Q9P0N8
Entrez Gene ID: (Human) 51257
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