|ELISA (ELISA)||Assay Dependent|
|Flow Cytometry (Flow)||1:10 -1:100|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant soluble MAdCAM-1-fc fusion protein|
|Contains||0.09% sodium azide|
|Storage conditions||4°C or -20°C if preferred|
Clone 314G8 recognizes human MAdCAM-1 under non-reducing conditions. For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul. In Western blot, this antibody detects a band at ~60 kDa.
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hMAdCAM-1; MACAM1,MAdCAM-1; MAdCAM-1; Mucosal addressin cell adhesion molecule 1; mucosal addressin cell adhesion molecule-1
Gene Aliases: MACAM1; MADCAM1
UniProt ID: (Human) A5PKV4
Entrez Gene ID: (Human) 8174
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