|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 62 and 490 of Human MDMX|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28212 targets MDMX in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-28212 immunogen is recombinant protein fragment corresponding to a region within amino acids 62 and 490 of Human MDMX.
The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Two transcript variants, one protein-coding and the other likely not to be protein-coding, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Double minute 4 protein; double minute 4, human homolog of; p53-binding protein; HDMX, MDMX, MRP1, MDM4-related protein 1, Mdm4, transformed 3T3 cell double minute 4, p53 binding protein, double minute 4, human homolog of; Mdm2-like p53-binding protein; Mdm4 p53 binding protein homolog; MDM4 protein variant G; MDM4 protein variant Y; MDM4-related protein 1; p53-binding protein Mdm4; p53-binding protein, mdm2-like p53-binding protein, protein Mdm4, protein Mdmx; Protein Mdm4; Protein Mdmx
Gene Aliases: HDMX; MDM4; MDMX; MRP1
UniProt ID: (Human) O15151
Entrez Gene ID: (Human) 4194
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