|Immunohistochemistry (Paraffin) (IHC (P))||5-10 ug/ml|
|Western Blot (WB)||0.3-1 ug/ml|
|Western Blot (WB)||See 1 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (PTEPVKRSGRYH) corresponding to the internal amino acids of PSMB10|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 in the immunoproteasome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: beta2i; LMP10; Low molecular mass protein 10; Macropain subunit MECl-1; MECL1; MGC1665; Multicatalytic endopeptidase complex subunit MECl-1; proteasome (prosome, macropain) subunit, beta type, 10; proteasome beta 10 subunit; proteasome catalytic subunit 2i; Proteasome MECl-1; proteasome subunit beta 7i; Proteasome subunit beta type-10; Proteasome subunit beta-2i; proteasome subunit MECL1; PSMB10
Gene Aliases: beta2i; LMP10; MECL1; PSMB10
UniProt ID: (Human) P40306
Entrez Gene ID: (Human) 5699
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