|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 411 and 651 of Human MED17|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30314 targets MED17 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-30314 immunogen is recombinant fragment corresponding to a region within amino acids 411 and 651 of Human MED17.
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 77kDa; Activator-recruited cofactor 77 kDa component; ARC77; cofactor required for Sp1 transcriptional activation; Cofactor required for Sp1 transcriptional activation subunit 6; cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa; CRSP complex subunit 6; CRSP6; CRSP77; DRIP80; Mediator complex subunit 17; Mediator of RNA polymerase II transcription subunit 17; subunit 6; thyroid hormone receptor-associated protein complex 80; Thyroid hormone receptor-associated protein complex 80 kDa component; Transcriptional coactivator CRSP77; TRAP80; Vitamin D3 receptor-interacting protein complex 80 kDa component
Gene Aliases: ARC77; CRSP6; CRSP77; DRIP77; DRIP80; MED17; TRAP80
UniProt ID: (Human) Q9NVC6
Entrez Gene ID: (Human) 9440
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