|Western Blot (WB)||0.5-2 µg/ml|
|Tested Species reactivity||Mouse, Human, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (72 RPHTGNVAIPQVTSVESK 89) of MERTK protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
MERTK is a novel transmembrane, receptor-like tyrosine kinase belonging to the MER/AXL/TYRO3 receptor kinase family with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and a tyrosine kinase domain. MERTK, a membrane protein, may have a functional role in filovirus infection, where it may act as a cell entry factor. MERTK is a GAS6 receptor, participating through binding to GAS6 in platelet function and platelet dependent thrombosis in vitro. Defects in MERTK have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). It is usually detected in normal peripheral blood monocytes, macrophages, bone marrow, and tissues of epithelial and reproductive origin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: c-mer; MER; MER receptor tyrosine kinase; proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase Mer; receptor tyrosine kinase MerTK; RP38; STK kinase; Tyro 12; tyrosine-protein kinase Mer
Gene Aliases: c-mer; Eyk; MER; nmf12; Nyk; RP38
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