|ELISA (ELISA)||Assay Dependent|
|Tested Species reactivity||Chemical|
|Host / Isotype||Sheep / IgG|
|Immunogen||Methotrexate (4-amino-10-methylpteroyl-L-glutamic acid) conjugated via the carboxyl groups of the glutamic acid residue to KLH.|
|Storage buffer||whole serum|
|Contains||0.09% sodium azide|
|Storage conditions||4°C or -20°C if preferred|
Methotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. [National Center for Biotechnology Information. PubChem Compound Database; CID=126941]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Abitrexate; Amethopterin; C20H22N8O5; Ledertrexate; Rheumatrex
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