|Western Blot (WB)||1:1000-1:10,000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 331 and 543 of MKL1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Contains||0.025% ProClin 300|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. [provided by RefSeq].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: basic, SAP and coiled-coil domain; BSAC; MAL; Megakaryoblastic leukemia 1 protein; megakaryoblastic leukemia translocation 1; Megakaryocytic acute leukemia protein; MKL/myocardin-like protein 1; MRTF-A; Myocardin-related transcription factor A
Gene Aliases: BSAC; KIAA1438; MAL; MKL1; MRTF-A
UniProt ID: (Human) Q969V6
Entrez Gene ID: (Human) 57591
Molecular Function: transcription factor
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