|Immunofluorescence (IF)||Assay Dependent|
|Immunocytochemistry (ICC)||See 3 publications below|
|Immunohistochemistry (IHC)||See 15 publications below|
|Miscellaneous PubMed (MISC)||See 1 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Rat , Sheep , Human|
|Host / Isotype||Mouse / IgG2b, kappa|
|Immunogen||Recombinant human matrilysin (PUMP-1)|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage conditions||4° C|
MA5-14215 targets MMP-7 (Matrilysin) in IF applications and shows reactivity with Human samples.
The MA5-14215 immunogen is recombinant human matrilysin (PUMP-1).
Matrix metalloproteinases (MMP) are proteolytic enzymes capable of degrading connective tissue components. Imbalanced secretion of certain MMP or disturbances in the differential control of MMP by tissue inhibitor of MMPs (TIMPs) are implicated in the invasive potential of malignant tumors. The matrix metalloproteinase, matrilysin/MMP-7/PUMP-1, is thought to play an important role in the early steps of tumor progression. Expression of MMP2, -7, and -11 is greater in pancreatic carcinoma than in normal pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Matrilysin; Matrin; matrix metallopeptidase 7 (matrilysin, uterine); matrix metalloproteinase 7 (matrilysin; matrix metalloproteinase 7 (matrilysin, uterine); Matrix metalloproteinase-7; MMP-7; Pump-1 protease; uterine matrilysin; Uterine metalloproteinase; uterine)
Gene Aliases: MMP-7; MMP7; MPSL1; PUMP-1; PUMP1
UniProt ID: (Human) P09237
Entrez Gene ID: (Human) 4316
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