|Immunofluorescence (IF)||Assay dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10|
|Western Blot (WB)||0.5-1 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||APMA (4-Aminophenylmercuric acetate) activated Human stromelysin-1 (SL-1).|
|Storage buffer||PBS, pH 7.4, with 1% BSA|
|Storage conditions||4° C, do not freeze|
MA1-21234 detects MMP-3 in human samples.
MA1-21234 has been successfully used in immunofluorescence, immunohistochemistry (Paraffin) and Western blot procedures. Suggested positive controls include conditioned, serum-free medium from TPA treated human endometrial cells, placenta, bladder, breast, and ovarian carcinomas.
MA1-21234 immunogen is APMA (4-Aminophenylmercuric acetate) activated human stromelysin-1 (SL-1).
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP3 is an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. MMP3 is reported to be implicated in rheumatoid arthritis and some forms of cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CHDS6; matrix metalloproteinase 3 (stromelysin 1, progelatinase); Matrix metalloproteinase-3; MGC126102; MGC126103; MGC126104; MMP-3; proteoglycanase; SL-1; STMY; STMY1; STR1; Stromelysin-1; Transin-1
Gene Aliases: CHDS6; MMP-3; MMP3; SL-1; STMY; STMY1; STR1
UniProt ID: (Human) P08254
Entrez Gene ID: (Human) 4314
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