|Immunohistochemistry (Paraffin) (IHC (P))||1 - 5 ug/ml|
|Western Blot (WB)||1-2 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||See 1 publications below|
|Immunohistochemistry (IHC)||See 1 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Synthetic peptide derived from the c-terminus of the human MMP-9 protein.|
|Contains||0.08% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Antigen retrieval is required for tissue staining: use 10mM citrate buffer and microwave method. A suggested positive control for this product is colon, esophageal or gastric tissues.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB; macrophage gelatinase; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); Matrix metalloproteinase-9; MMP-9; type V collagenase
Gene Aliases: CLG4B; GELB; MANDP2; MMP-9; MMP9
UniProt ID: (Human) P14780
Entrez Gene ID: (Human) 4318
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