|Western Blot (WB)||0.5-1 ug/ml|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 15 amino acid peptide near the carboxy terminus of human MMS21.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is 293 cell lysate.
PA5-20962 can be used with blocking peptide PEP-1076.
MMS21, also known as NSE2, is a SUMO ligase that in combination with the SMC5/6 complex is required for the prevention of DNA damage induced apoptosis by facilitating DNA repair in human cells. MMS21-dependent sumoylation is integral and important to the cohesion mechanism and mitotic progression; this function appears to be independent of SMC6. MMS21 mediates SUMO attachment to various proteins such as SMC6L1 and TRAX, and possibly the cohesin components RAD21 and STAG2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C8orf36, MMS21, NSE2; E3 SUMO-protein ligase NSE2; hMMS21; methyl methanesulfonate sensitivity gene 21; MMS21 homolog; Non-SMC element 2 homolog; non-SMC element 2, MMS21 homolog; Non-structural maintenance of chromosomes element 2 homolog; zinc finger, MIZ-type containing 7
Gene Aliases: 1110014D18Rik; AI661537; C8orf36; MMS21; NSE2; NSMCE2; RGD1305156; ZMIZ7
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