|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
|Western Blot (WB)||1-2 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a portion of human MRE11.|
|Contains||0.02% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Suggested positive control: 293 whole cell lysate.
MRE11 in yeast belongs to RAD50 epistasis group gene, MRE11, blocks meiotic recombination and play roles in non-homologous end-joining (NHEJ) DNA double-strand break (DSB) repair pathways. Human MRE11 shares approximately 50% identity at the amino acid level with its yeast counterpart in the N-terminal half of the protein (1). Repair of DNA double-strand breaks by radiation is dependent on a multifunctional complex containing Rad50, MRE11, and the NBS1 gene product, p95 (NBS protein, nibrin) (2). In addition function of MRE11 is also linked to ataxia telangiectasia mutated (ATM) protein kinase (3), TTAGGG repeat binding factor2 (TRF2) (4), and Ku70 (5). A mutation of the hMRE11 gene may be important in a new ataxia telangiectasia-like disorder (ATLD) (6). MRE11 is expressed at the highest levels in proliferating tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AT-like disease; ATLD; DNA recombination and repair protein; Double-strand break repair protein MRE11; Double-strand break repair protein MRE11A; endo/exonuclease Mre11; HNGS1; Meiotic recombination 11 homolog 1; Meiotic recombination 11 homolog A; MRE11; MRE11 double strand break repair nuclease A; MRE11 homolog 1; MRE11 homolog A; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; MRE11 meiotic recombination 11-like protein A; MRE11B
Gene Aliases: ATLD; HNGS1; MRE11; MRE11A; MRE11B
UniProt ID: (Human) P49959
Entrez Gene ID: (Human) 4361
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