|Immunohistochemistry (Paraffin) (IHC (P))||2-4ug/ml|
|Western Blot (WB)||0.1-0.3ug/ml|
|Tested Species reactivity||Human, Mouse, Rabbit|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (APKQDPKPKFQEG) corresponding to the N-terminus amino acids of MORF4L1|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with bovine, human, porcine and rat based on sequence homology.
Cellular senescence is the terminal non-dividing state that normal cells enter following completion of their proliferative potential. Fusions of immortal human cell lines with each other have led to their assignment to one of four complementation groups. Mortality factor 4 (MORF4) was identified as the lead member of a family of transcription factor-like proteins that reverses this immortal phenotype. Like other members in this family, MORF4 is localized to the nucleus and possesses transcription factor-like motifs such as helix-loop-helix and a leucine zipper motif that might allow it to form transcriptionally active homo- or heterodimers. MORF4 has been shown to bind to the transcription corepressors mSin3A and TLE, suggesting that together, these complexes may play a role in transcriptional repression of genes that lead to cellular senescence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Eaf3; Esa1p-associated factor 3 homolog; FWP006; HsT17725; MEAF3; MGC10631; MORF-related gene 15; MORF-related gene 15 protein; MORF-related gene on chromosome 15; MORF4L1; MORFRG15; mortality factor 4 like 1; Mortality factor 4-like protein 1; MRG15; testis expressed gene 189; Testis-expressed gene 189 protein; Transcription factor-like protein MRG15
Gene Aliases: mKIAA4002; Morf4l1; MORFRG15; MRG15; TEG-189; Tex189
UniProt ID: (Mouse) P60762
Entrez Gene ID: (Mouse) 21761
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