|Immunocytochemistry (ICC)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||12 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 14 amino acid peptide from N-terminal extracellular domain of human MRGPRX1 / MRGX1.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human, Monkey (100%) Gibbon (93%).
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: G protein-coupled receptor MRGX1; G protein-coupled receptor SNSR3; Mas-related G protein-coupled receptor G2; Mas-related G-protein coupled receptor member X1; MAS-related GPR; MAS-related GPR, member X1; member X1; MRGPRX1; MRGX1; Sensory neuron-specific G-protein coupled receptor 3/4; SNSR3; SNSR4
Gene Aliases: GPCR; MGRG2; MRGPRX1; MRGX1; SNSR3; SNSR4
UniProt ID: (Human) Q96LB2
Entrez Gene ID: (Human) 259249
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