|Immunohistochemistry (Paraffin) (IHC (P))||1:25-1:50|
|Western Blot (WB)||1:100-1:500|
|Blocking Assay (BLOCK)||See 3 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Synthetic peptide human MSH6|
|Storage conditions||4° C, do not freeze|
MA1-34550 detects MSH6 from human samples.
MA1-34550 has been successfully used in immunohistochemistry (paraffin tissue), Western blot applications. Formalin-fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0, prior to staining. Positive controls: colon carcinoma, tonsil.
The MA1-34550 immunogen is: Synthetic peptide human MSH6
The DNA mismatch repair MSH2/MSH6 heterodimer is responsible for the detection of DNA damage, and may promote apoptosis in normal cells, thus protecting mammals from ultraviolet-induced malignant transformation and hence the prevention of skin cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; HNPCC5; HSAP; mutS-alpha 160 kDa subunit; sperm-associated protein
Gene Aliases: GTBP; GTMBP; HNPCC5; HSAP; p160
UniProt ID: (Human) B4DF41
Entrez Gene ID: (Human) 2956
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