|Western Blot (WB)||1ug/ml|
|Tested Species reactivity||Mouse|
|Host / Isotype||Rat / IgG2c|
|Immunogen||MTGR1 peptide coupled BSA.|
|Contains||0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CBFA2T2 identified gene homolog; core-binding factor runt domain alpha subunit 2 translocated to 2 homolog; core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog; DKFZp313F2116; EHT; MTG8-like protein; MTG8-related protein 1; Protein CBFA2T2; ZMYND3 CBFA2T2
Gene Aliases: A430091M07; C330013D05Rik; Cbfa2t2; Cbfa2t2h; MTGR1
UniProt ID: (Mouse) O70374
Entrez Gene ID: (Mouse) 12396
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