|Western Blot (WB)||0.1-0.3 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (HISTDAHSLNSAAQ) corresponding to the C-terminus amino acids of MUTYH|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: A/G-specific adenine DNA glycosylase; Adenine DNA glycosylase; CYP2C; hMYH; MGC4416; mutY (E. coli) homolog; MutY homolog; mutY homolog (E. coli); mutY-like protein; MUTYH; MYH; OTTHUMP00000009098; OTTHUMP00000009102; RP4-534D1.2
Gene Aliases: MUTYH; MYH
UniProt ID: (Human) Q9UIF7
Entrez Gene ID: (Human) 4595
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