|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 197 of Macro H2A.2 (Uniprot ID#Q9P0M6)|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
The PA5-34877 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 197 of Macro H2A.2 (Uniprot ID#Q9P0M6).
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Core histone macro-H2A.2; core histone macroH2A2.2; H2A histone family, member Y2; H2AFY2; Histone macroH2A2; macroH2A2; mH2A2
Gene Aliases: H2AFY2; MACROH2A2
UniProt ID: (Human) Q9P0M6
Entrez Gene ID: (Human) 55506
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