|Immunohistochemistry (Paraffin) (IHC (P))||1:2000|
|Western Blot (WB)||1:50|
|Immunocytochemistry (ICC)||See 1 publications below|
|Immunohistochemistry (IHC)||See 16 publications below|
|Tested Species reactivity||Dog, Cat, Human, Non-human primate|
|Published species reactivity||Rat , Human Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human mast cell tryptase purified from human lung tissues|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage conditions||4° C|
MA5-11711 targets Mast Cell Tryptase in IHC (P) and WB applications and shows reactivity with Canine, Feline, Human, and Non-human primate samples.
The MA5-11711 immunogen is human mast cell tryptase purified from human lung tissues.
Mast cells contain a number of preformed chemical mediators such as histamine, chymase, carboxypeptidase and proteolytic tryptase. A substantial quantity of tryptase is estimated to be found in mast cells of skin and lung and suggestes this enzyme plays a major role in mast cell mediated events. In vitro studies indicate tryptase can cleave C3 to form C3a anaphylatoxin, inactivate fibrinogen as a coaguable substrate for thrombin and activate latent collagenase. Human mast cell tryptase has considerable potential as a marker for mast cell activation as well as being a mediator of inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: mast cell alpha II tryptase; mast cell beta I tryptase; tryptase alpha II; Tryptase alpha-1; Tryptase alpha/beta-1; tryptase beta 1; tryptase beta I; tryptase beta-1; Tryptase I; Tryptase-1; tryptase-I; tryptase-III
Gene Aliases: TPS1; TPS2; TPSAB1; TPSB1
UniProt ID: (Human) Q15661
Entrez Gene ID: (Human) 7177
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule
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