|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 1202-1231 amino acids from human MUC1|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This gene is a member of the mucin family and encodes amembrane bound, glycosylated phosphoprotein. The protein isanchored to the apical surface of many epithelia by a transmembranedomain, with the degree of glycosylation varying with cell type. Italso includes a 20 aa variable number tandem repeat (VNTR) domain,with the number of repeats varying from 20 to 120 in differentindividuals. The protein serves a protective function by binding topathogens and also functions in a cell signaling capacity.Overexpression, aberrant intracellular localization, and changes inglycosylation of this protein have been associated with carcinomas.Multiple alternatively spliced transcript variants that encodedifferent isoforms of this gene have been reported, but thefull-length nature of only some has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Breast carcinoma-associated antigen DF3; CA 15-3; Cancer antigen 15-3; Carcinoma-associated mucin; CD227; DF3 antigen; EMA; Episialin; Epithelial Membrane Antigen; H23 antigen; H23AG; KL-6; Krebs von den Lungen-6; MAM6; Medullary cystic kidney disease, autosomal dominant; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; mucin 1, transmembrane; Mucin-1; Peanut-reactive urinary mucin; PEM; PEMT; Polymorphic epithelial mucin; PUM; tumor associated epithelial mucin; Tumor-associated epithelial membrane antigen; Tumor-associated mucin
Gene Aliases: ADMCKD; ADMCKD1; CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MCD; MCKD; MCKD1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1; MUC1/ZD; PEM; PEMT; PUM
UniProt ID: (Human) Q9UE76
Entrez Gene ID: (Human) 4582
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