|Immunohistochemistry (IHC)||1-10 µg/ml|
|Western Blot (WB)||1-10 µg/ml|
|Immunohistochemistry (IHC)||See 2 publications below|
|Tested Species reactivity||Goat, Human, Mouse, Non-human primate, Sheep, Rabbit, Rat|
|Published species reactivity||Marsupial Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Purified human myelin basic protein.|
|Storage buffer||PBS, pH 7.4|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
MA1-10837 detects Myelin Basic Protein from human, non-human primate, rabbit, sheep, goat, rat, and mouse samples.
MA1-10837 has been successfully used in ELISA, Western blot, and immunohistochemistry applications.
The MA1-10837 immunogen is purified human myelin basic protein.
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Golli-mbp; Golli-Mbp; myelin basic protein; Golli-Mbp; myelin basic protein; myelin basic protein S; MBP; MBP S; Myelin A1 protein; Myelin basic protein; myelin basic protein Golli-mbp; myelin basic protein S; myelin deficient; Myelin membrane encephalitogenic protein; myelin-associated oligodendrocytic basic protein-like; shiverer
Gene Aliases: C76307; golli-mbp; Hmbpr; MBP; Mbps; mld; R75289; Shi
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