|Flow Cytometry (Flow)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Bovine, Dog, Human, Mouse, Non-human primate, Rat|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Synthetic peptide GRGTKF corresponding to C terminal region of myelin proteolipid protein|
|Contains||0.09% sodium azide|
|Storage conditions||4°C or -20°C if preferred|
Predicted to react with all mammals based on sequence homology.
This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HLD1; Lipophilin; major myelin proteolipid protein; MMPL; Myelin proteolipid protein; myelin synthesis deficiency; PLP; PLP/DM20; PMD; proteolipid protein (myelin) 1; Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated); Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated); proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated); rump shaker; SPG2
Gene Aliases: BOS_25620; DM20; GPM6C; HLD1; jimpy; jp; MMPL; msd; PLP; PLP/DM20; PLP1; PMD; rsh; SPG2
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