|Western Blot (WB)||1:5000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide made to an N-terminal region of the human MyoD1 protein (within residues 1-150).|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.1% BSA, 50% glycerol|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
The target sequence has 90% sequence homology with mouse.
In muscle cell development and differentiation, MYOD1 is a key transcription factor regulating myogenesis. In skeletal muscle, MYOD1 works in tandem with PC4 to promote MEF2C transcription, and thus regeneration of muscle following injury. MYOD1 also influences normal muscle cell formation. Unsurprisingly, MYOD1 is then associated with several diseases of muscle groups, including infantile myofibroma, rhabdomyosarcoma, ulcerative colitis, and sclerosis. MYOD1 is also found in atypical cells of orbital pleomorphic liposarcoma in children.
Protein Aliases: bHLHc1; Class C basic helix-loop-helix protein 1; Myf-3; MYF3; Myoblast determination protein 1; MYOD; Myogenic factor 3
Gene Aliases: BHLHC1; MYF3; MYOD; MYOD1; PUM
UniProt ID: (Human) P15172
Entrez Gene ID: (Human) 4654