|Western Blot (WB)||1:200-1:1000|
|Immunohistochemistry (Paraffin) (IHC (P))||See 2 publications below|
|Tested Species reactivity||Human, Mouse|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||MBP fusion protein containing the full cytoplasmic domain of human N-cadherin|
|Storage buffer||PBS with 1mg/ml BSA, 30% glycerol|
|Contains||0.05% sodium azide|
N-cadherin is a calcium-dependent cell-cell adhesion glycoprotein comprising five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail with a predicted molecular weight of ~90 kDa. N-cadherin is required during gastrulation for proper establishment of the left-right axis. Full length and soluble N-cadherin have been shown to promote cell-matrix adhesion and neurite outgrowth. It has been reported that aberrant expression of N-cadherin by cancer cells can contribute to invasiveness and metastasis by making the cells more motile.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cadherin 2, type 1, N-cadherin (neuronal); Cadherin-2; Calcium-Dependent Adhesion Protein; calcium-dependent adhesion protein, neuronal; CD325; CD325 Neural cadherin; CDw325; N-cadherin; N-cadherin 1; Neural cadherin
Gene Aliases: CD325; CDH2; CDHN; CDw325; N-cadherin; NCAD
Molecular Function: cadherin
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