|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant, full length human NALP1 (pyrin domain).|
|Purification||Size-exclusion - Gel filtration|
|Contains||0.02% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
MA1-25842 detects NALP1 from human samples.
MA1-25842 has been successfully used in immunocytochemistry, immunohistochemistry (frozen), immunohistochemistry (paraffin), immunoprecipitation, immunofluorescence and Western blot procedures.
The MA1-25842 immunogen is recombinant, full length human NALP1 (pyrin domain).
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CARD7; caspase recruitment domain protein 7; Caspase recruitment domain-containing protein 7; CLR17.1; Death effector filament-forming ced-4-like apoptosis protein; DEFCAP; DEFCAP-L/S; DKFZp586O1822; KIAA0926; NAC; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; NACHT, LRR and PYD domains-containing protein 1; NALP1; NLR family, pyrin domain containing 1; Nucleotide-binding domain and caspase recruitment domain; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1; PP1044; SLEV1; VAMAS1
Gene Aliases: CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; KIAA0926; NAC; NALP1; NLRP1; PP1044; SLEV1; VAMAS1
UniProt ID: (Human) Q9C000
Entrez Gene ID: (Human) 22861
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