|Immunocytochemistry (ICC)||25 ug/ml|
|Western Blot (WB)||1 - 2 ug/mL|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 17 amino acid peptide near the center of human NCBP1|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is Hela cell lysate.
PA5-34567 can be used with blocking peptide PEP-1610.
NCBP1, also known as CBP80, is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. NCBP1 promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Recent evidence has shown that cellular-cap-binding proteins such as NCBP1 associate with influenza virus mRNAs, suggesting that these viral mRNAs may follow the normal cellular pathways for splicing, nuclear export, and translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 80 kDa nuclear cap-binding protein; CBP80; NCBP 80 kDa subunit; NCBP1; nuclear cap binding protein subunit 1, 80kD; nuclear cap binding protein subunit 1, 80kDa; Nuclear cap-binding protein 1; Nuclear cap-binding protein subunit 1; Sto1
Gene Aliases: AU014645; AW538051; CBP80; NCBP; NCBP1; Sto1
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